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M-CSF Rekombinanter Antikörper

M-CSF Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241743C5

Kat-Nr. : 84481-4-PBS

Synonyme

M CSF, Lanimostim, CSF-1, CSF1, CSF 1

Filter:
  • Western Blot (WB) analysis of various lysates using M-CSF Recombinant antibody (84481-4-RR)

    WB analysis using 84481-4-RR (same clone as 84481-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84481-4-RR (MCSF antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84481-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84481-4-RR

    Affinity and Kinetic Characterization of 84481-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84481-4-RR against Human M-CSF were performed. The affinity constant is 11.4 nM.

Geprüfte Anwendungen

Produktinformation

84481-4-PBS bindet in WB, Indirect ELISA M-CSF und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name colony stimulating factor 1 (macrophage)
Berechnetes Molekulargewicht 60 kDa
Beobachtetes Molekulargewicht60 kDa
GenBank-ZugangsnummerBC021117
Gene symbol M-CSF
Gene ID (NCBI) 1435
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

M-CSF plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes. M-CSF promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It also plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. On the cellular level, M-CSF promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration and plays a role in lipoprotein clearance (PMID: 29734839; 29679908; 28202039)