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MEGF8 Polyklonaler Antikörper

MEGF8 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 32300-1-PBS

Synonyme

Multiple EGF-like domains protein 8, KIAA0817, Epidermal growth factor-like protein 4, EGF-like protein 4, EGFL4

Filter:
  • Western Blot (WB) analysis of various lysates using MEGF8 Polyclonal antibody (32300-1-AP)

    WB analysis using 32300-1-AP (same clone as 32300-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 32300-1-AP (MEGF8 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32300-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

32300-1-PBS bindet in WB, Indirect ELISA MEGF8 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen MEGF8 fusion protein Ag36469
Vollständiger Name multiple EGF-like-domains 8
Berechnetes Molekulargewicht303 kDa
Beobachtetes Molekulargewicht303 kDa
GenBank-ZugangsnummerNM_001271938.1
Gene symbol MEGF8
Gene ID (NCBI) 1954
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Multiple epidermal growth factor-like domains protein 8 (MEGF8, also known as C19orf49, EGFL4, and KIAA0817) is a multidomain transmembrane protein, which is known to interact with MGRN1, a protein that functions as an E3 ubiquitin ligase, and this interaction is involved in the regulation of Hedgehog signaling and heart development (PMID: 32966817). It is also involved in mediating Bone morphogenetic protein 4 (BMP4) signaling and guidance of developing trigeminal ganglion (TG) axons (PMID: 24052814). Immunoelectron microscopy showed that MEGF8 was present in the synapses and around the outer mitochondrial membrane, indicating its role in synaptic and mitochondrial functions (PMID: 38201267).