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MICA/MICB Rekombinanter Antikörper

MICA/MICB Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

240735D5

Kat-Nr. : 98110-1-PBS

Synonyme

MICB, MICA, 240735D5, MIC A, PERB11.1

Filter:
  • Flow cytometry (FC) experiment of HeLa cells using Anti-Human MICA/MICB Rabbit Recombinant Antibody (98110-1-RR)

    FC experiment of HeLa using 98110-1-RR (same clone as 98110-1-PBS)

    1x10^6 HeLa cells (left) or Jurkat cells (right) were surface stained with 0.25 ug Anti-Human MICA/MICB Rabbit Recombinant Antibody (98110-1-RR, Clone: 240735D5) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (red), or 0.25 ug Isotype Control (blue). Cells were not fixed. This data was developed using the same antibody clone with 98110-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98110-1-RR

    Affinity and Kinetic Characterization of 98110-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98110-1-RR against Human MICA were performed. The affinity constant is 0.907 nM.

Geprüfte Anwendungen

Produktinformation

98110-1-PBS bindet in FC MICA/MICB und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen MICA/MICB fusion protein Eg1176
Vollständiger Name MHC class I polypeptide-related sequence A
Berechnetes Molekulargewicht43 kDa
GenBank-ZugangsnummerAAH16929.1
Gene symbol MICA
Gene ID (NCBI) 4276
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

Human MHC class I chain-related genes located within the HLA class I region of chromosome 6 encode MHC class I chain-related A and B (MICA and MICB) (PMID: 11429322). MICA and MICB are stress-inducible surface molecules that are not associated with β2-microglobulin and do not present peptides (PMID: 9497295). They are expressed in intestinal epithelium and many epithelial tumors (PMID: 10359807). MICA and MICB are ligands for NKG2D which is an activating receptor that is expressed on most natural killer (NK) cells, CD8 αβ T cells, and γδ T cells (PMID: 10426993; 11491531). This antibody recognizes both MICA and MICB.