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MICALL1 Polyklonaler Antikörper

MICALL1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 33503-1-PBS

Synonyme

KIAA1668, MICAL Like 1, MICAL-L1, MICAL-Like 1, MICAL-like protein 1

Filter:
  • Western Blot (WB) analysis of various lysates using MICALL1 Polyclonal antibody (33503-1-AP)

    WB analysis using 33503-1-AP (same clone as 33503-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 33503-1-AP (MICALL1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33503-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

33503-1-PBS bindet in WB, Indirect ELISA MICALL1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen MICALL1 fusion protein Ag39169
Vollständiger Name MICAL-like 1
Berechnetes Molekulargewicht93kDa，863aa
Beobachtetes Molekulargewicht125 kDa
GenBank-ZugangsnummerNM_033386.3
Gene symbol MICALL1
Gene ID (NCBI) 85377
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

MICALL1 (MICAL-like protein 1) is a protein involved in the regulation of cytoskeleton dynamics and is a member of the MICAL family. This protein interacts with other molecules through its N-terminal CH domain and C-terminal coiled-coil domain, primarily regulating the stability of microtubules and actin, thereby affecting processes such as cell shape, migration, and intracellular transport. Studies have shown that MICALL1 plays a key role in neuronal axon guidance, angiogenesis, and the establishment of epithelial cell polarity. Additionally, it binds to Rab GTPases (such as Rab8a) and is involved in vesicle transport and membrane remodeling. Aberrant expression of MICALL1 is associated with tumor metastasis and neurological diseases, with its molecular mechanisms involving precise regulation of cytoskeleton rearrangement, making it a potential therapeutic target.