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CCL3/MIP-1 alpha Polyklonaler Antikörper

CCL3/MIP-1 alpha Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 27441-1-PBS

Synonyme

CCL3, MIP 1 alpha/CCL3, MIP-1 alpha, MIP-1 Alpha/CCL3, C C motif chemokine 3

Filter:
  • Western Blot (WB) analysis of various lysates using CCL3/MIP-1 alpha Polyclonal antibody (27441-1-AP)

    WB analysis using 27441-1-AP (same clone as 27441-1-PBS)

    PMA, LPS, and Brefeldin A treated THP-1 cells were subjected to SDS PAGE followed by western blot with 27441-1-AP (MIP 1 alpha/CCL3 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27441-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

27441-1-PBS bindet in WB, Indirect ELISA CCL3/MIP-1 alpha und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen CCL3/MIP-1 alpha fusion protein Ag26764
Vollständiger Name chemokine (C-C motif) ligand 3
Berechnetes Molekulargewicht 92 aa, 10 kDa
Beobachtetes Molekulargewicht10 kDa
GenBank-ZugangsnummerBC071834
Gene symbol CCL3/MIP-1 alpha
Gene ID (NCBI) 6348
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Chemokine (C-C motif) ligand 3 (CCL3), also known as MIP-1α, belongs to the family of chemokines. CCL3 has been found in the central nervous system and its cognate receptors, CCR1 and CCR5, have been reported to be expressed by astrocytes, microglia and neurons. CCL3 and its receptors, CCR1 and CCR5, also contribute to the development of bone disease in multiple myeloma by supporting tumor growth and regulating osteoclast differentiation. CCL3 is also associated with the regulation of cell growth, angiogenesis, and metastasis of different tumors such as melanoma, renal cell carcinoma, and colorectal cancer. Moreover, CCL3 enhances cell migration and metastasis by up-regulating matrix metalloproteinase-2 (MMP)-2 expression in chondrosarcoma cells.