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MIST1 Polyklonaler Antikörper

MIST1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 29853-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using MIST1 Polyclonal antibody (29853-1-AP)

    WB analysis using 29853-1-AP (same clone as 29853-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 29853-1-AP (MIST1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29853-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

29853-1-PBS bindet in WB, Indirect ELISA MIST1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen MIST1 fusion protein Ag32096
Vollständiger Name basic helix-loop-helix family, member a15
Berechnetes Molekulargewicht21 kDa
Beobachtetes Molekulargewicht20-30 kDa
GenBank-ZugangsnummerNM_177455
Gene symbol MIST1
Gene ID (NCBI) 168620
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Muscle intestine stomach expression 1 (MIST1), also named BHLHA15, is a secretory cell transcription factor that belongs to the basic helix-loop-helix superfamily. MIST1 is mainly expressed in serous secreted cells and essential for the development and maturation of secretory cells. Secretory cells lacking MIST1 exhibit structural and functional defects, including alterations in cytoskeletal organization and cell polarity and improper cell-cell junction. In healthy pancreata, MIST1 facilitates cell-to-cell communication, promotes acinar cell polarity, controls Ca2+ flux, promotes unfolded protein response (UPR) homeostasis, aids in vesicle assembly, and is required for regulated exocytosis. MIST1 was downregulated in pancreatic cancer tissues compared with normal or adjacent pancreatic tissues and lower MIST1 expression in pancreatic cancer cell lines than normal acinar cells (PMID:29859299).