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MIST1 Monoklonaler Antikörper

MIST1 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

Hausschwein, human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

1E10B3

Kat-Nr. : 68092-1-PBS

Synonyme

BHLHA15, MIST 1, MIST1

Filter:
  • Western Blot (WB) analysis of various lysates using MIST1 Monoclonal antibody (68092-1-Ig)

    WB analysis using 68092-1-Ig (same clone as 68092-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68092-1-Ig (MIST1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68092-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

68092-1-PBS bindet in WB, Indirect ELISA MIST1 und zeigt Reaktivität mit Hausschwein, human, Maus, Ratten

Getestete Reaktivität Hausschwein, human, Maus, Ratte
Wirt / Isotyp Maus / IgG2a
Klonalität Monoklonal
Typ Antikörper
Immunogen MIST1 fusion protein Ag18509
Vollständiger Name basic helix-loop-helix family, member a15
Berechnetes Molekulargewicht 189 aa, 21 kDa
Beobachtetes Molekulargewicht27 kDa
GenBank-ZugangsnummerBC113394
Gene symbol MIST1
Gene ID (NCBI) 168620
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Muscle intestine stomach expression 1 (MIST1), also named bHLHa15, is a secretory cell transcription factor that belongs to the basic helix-loop-helix superfamily. MIST1 is mainly expressed in serous secreted cells and essential for the development and maturation of secretory cells. Secretory cells lacking MIST1 exhibit structural and functional defects, including alterations in cytoskeletal organization and cell polarity and improper cell-cell junction. In healthy pancreata, MIST1 facilitates cell-to-cell communication, promotes acinar cell polarity, controls Ca2+ flux, promotes unfolded protein response (UPR) homeostasis, aids in vesicle assembly, and is required for regulated exocytosis. MIST1 was downregulated in pancreatic cancer tissues compared with normal or adjacent pancreatic tissues and lower MIST1 expression in pancreatic cancer cell lines than normal acinar cells (BxPC-3, PANC-1, SW 1990) (PMID:29859299). MIST1 is downregulated in the development of gastric cancer and in gastric cancer cells compared with SW620 cells (PMID:34149921).