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MKL1/MRTF-A Rekombinanter Antikörper

MKL1/MRTF-A Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242021B4

Kat-Nr. : 84903-1-PBS

Synonyme

MKL1, MRTFA, MKL/myocardin-like protein 1, MAL, KIAA1438

Filter:
  • Western Blot (WB) analysis of various lysates using MKL1/MRTF-A Recombinant antibody (84903-1-RR)

    WB analysis using 84903-1-RR (same clone as 84903-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84903-1-RR (MKL1/MRTF-A antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84903-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84903-1-RR

    Affinity and Kinetic Characterization of 84903-1-RR

    Biolayer interferometry (BLl) kinetic assays of 84903-1-RR against Human MKL1/MRTF-A were performed. The affinity constant is below 1 pM.

Geprüfte Anwendungen

Produktinformation

84903-1-PBS bindet in WB, Indirect ELISA MKL1/MRTF-A und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen MKL1/MRTF-A fusion protein Ag15308
Vollständiger Name megakaryoblastic leukemia (translocation) 1
Berechnetes Molekulargewicht 931 aa, 99 kDa
Beobachtetes Molekulargewicht145-160 kDa
GenBank-ZugangsnummerBC115039
Gene symbol MKL1
Gene ID (NCBI) 57591
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Megakaryocytic leukemia 1 (MKL1), also known as myocardin-related transcription factor A (MRTF-A), is a transcriptional regulator involved in a wide range of pathophysiological processes in the cardiovascular system. MKL1 was initially identified as a co-factor for serum response factor (SRF) to regulate the transcription of contractile genes. Forced expression of MKL1 in non-muscle cells leads to robust up-regulation of contractile genes (PMID: 36587486, PMID: 37199168, PMID: 39222836). MKL1 is ubiquitously expressed and has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart, and brain. The molecular weight of MKL1 observed is consistent with what has been described in the literature (PMID: 34944031).