KMT2A Polyklonaler Antikörper

KMT2A Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 29278-1-PBS

Synonyme

MLL, HTRX, HRX, FLJ11783, CXXC7

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  WB analysis using 29278-1-AP (same clone as 29278-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 29278-1-AP (MLL antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29278-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

29278-1-PBS bindet in WB, Indirect ELISA KMT2A und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: KMT2A fusion protein Ag30468
• Vollständiger Name: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
• Berechnetes Molekulargewicht: 432 kDa
• Beobachtetes Molekulargewicht: 180 kDa
• GenBank-Zugangsnummer: NM_001197104
• Gene symbol: MLL
• Gene ID (NCBI): 4297
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

KMT2A, also known as mixed-lineage leukemia (MLL), is a gene that encodes a lysine methyltransferase responsible for the transcriptional activation through lysine 4 of histone 3 (H3K4) methylation. KMT2A is expressed mainly in the nucleus and is ubiquitously present in various tissues, particularly in ovary, lymph node, endometrium, thyroid, and brain tissue. It plays a significant role in embryonic development, hematopoiesis, and neurodevelopment. Mutations in KMT2A have been associated with several pathological conditions.