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MMP24 Polyklonaler Antikörper

MMP24 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 30102-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using MMP24 Polyclonal antibody (30102-1-AP)

    WB analysis using 30102-1-AP (same clone as 30102-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30102-1-AP (MMP24 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30102-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

30102-1-PBS bindet in WB, Indirect ELISA MMP24 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen MMP24 fusion protein Ag31597
Vollständiger Name matrix metallopeptidase 24 (membrane-inserted)
Berechnetes Molekulargewicht73KD
Beobachtetes Molekulargewicht55-58 kDa
GenBank-ZugangsnummerNM_006690
Gene symbol MMP24
Gene ID (NCBI) 10893
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes, such as arthritis or metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP24 (MT5-MMP) is a membrane type matrix metalloproteinase attached to the cell membrane by a transmembrane domain (PMID: 30654475). MMP24 is mainly expressed in the nervous system, hippocampus, and cerebellum (PMID: 10727639,35177031). MMP24 may negatively regulate the aggressiveness of cancer cells under the stiff ECM environment during tumor progression (PMID: 32093160). MMP24 can be detected as 62-65 kDa and 55-58 kDa (PMID: 16495457,20942921,10622708).