- Featured Product
- KD/KO Validated
MMP-9 (N-terminal) Polyklonaler Antikörper
MMP-9 (N-terminal) Polyklonal Antikörper für IF/ICC
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human
Anwendung
IF/ICC
Konjugation
CoraLite® Plus 488 Fluorescent Dye
Kat-Nr. : CL488-10375
Synonyme
Geprüfte Anwendungen
Erfolgreiche Detektion in IF/ICC | MCF-7-Zellen |
Empfohlene Verdünnung
Anwendung | Verdünnung |
---|---|
Immunfluoreszenz (IF)/ICC | IF/ICC : 1:50-1:500 |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, check data in validation data gallery |
Produktinformation
CL488-10375 bindet in IF/ICC MMP-9 (N-terminal) und zeigt Reaktivität mit human
Getestete Reaktivität | human |
Wirt / Isotyp | Kaninchen / IgG |
Klonalität | Polyklonal |
Typ | Antikörper |
Immunogen | MMP-9 (N-terminal) fusion protein Ag0552 |
Vollständiger Name | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) |
Berechnetes Molekulargewicht | 707 aa, 78 kDa |
Beobachtetes Molekulargewicht | 67 kDa, 92 kDa |
GenBank-Zugangsnummer | BC006093 |
Gene symbol | MMP-9 |
Gene ID (NCBI) | 4318 |
Konjugation | CoraLite® Plus 488 Fluorescent Dye |
Excitation/Emission maxima wavelengths | 493 nm / 522 nm |
Form | Liquid |
Reinigungsmethode | Antigen-Affinitätsreinigung |
Lagerungspuffer | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA |
Lagerungsbedingungen | Bei -20°C lagern. Vor Licht schützen. Nach dem Versand ein Jahr stabil. Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes, such as arthritis or metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (MMP9, synonyms: GELB, CLG4B) degrades collagens type IV and V. Studies in rhesus monkeys suggest that MMP9 is involved in IL-8-induced mobilization hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. The pro-MMP9 is 92 kDa, and it can be detected a processed form of 68 kDa. This protein can exist as a dimer of 180 kDa (PMID:7492685).
Protokolle
PRODUKTSPEZIFISCHE PROTOKOLLE | |
---|---|
IF protocol for CL Plus 488 MMP-9 (N-terminal) antibody CL488-10375 | Protokoll herunterladen |
STANDARD-PROTOKOLLE | |
---|---|
Klicken Sie hier, um unsere Standardprotokolle anzuzeigen |