CD206 Rekombinanter Antikörper

CD206 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

240344D12

Kat-Nr. : 98031-1-PBS

Synonyme

Mrc1, MR, MMR, mannose receptor, C type 1, 240344D12

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  FC experiment of mouse peritoneal macrophages using 98031-1-RR (same clone as 98031-1-PBS)

  1x10^6 mouse peritoneal macrophages were surface stained with 0.25 ug Anti-Mouse MMR/CD206 Rabbit Recombinant Antibody (98031-1-RR, Clone: 240344D12) or Isotype Control and PE-conjugated Goat Anti-Rabbit IgG. Cells were then stained with APC Anti-Mouse CD107b / LAMP2. Cells were not fixed. This data was developed using the same antibody clone with 98031-1-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse peritoneal macrophages using 98031-1-RR (same clone as 98031-1-PBS)

  1x10^6 mouse peritoneal macrophages were surface stained with 0.25 ug Anti-Mouse MMR/CD206 Rabbit Recombinant Antibody (98031-1-RR, Clone: 240344D12) (red) or Isotype Control (blue) and PE-conjugated Goat Anti-Rabbit IgG. Cells were not fixed. This data was developed using the same antibody clone with 98031-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98031-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98031-1-RR against Mouse CD206 were performed. The affinity constant is 75.8 nM.

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Geprüfte Anwendungen

Produktinformation

98031-1-PBS bindet in FC CD206 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: mannose receptor, C type 1
• Berechnetes Molekulargewicht: 165 kDa
• GenBank-Zugangsnummer: NM_008625.2
• Gene symbol: CD206
• Gene ID (NCBI): 17533
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia.