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MNT Polyklonaler Antikörper

MNT Polyklonal Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 23742-1-PBS

Synonyme

bHLHd3, Class D basic helix-loop-helix protein 3, MAD6, MAX binding protein, Max binding protein MNT

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  • Western Blot (WB) analysis of HeLa cells using MNT Polyclonal antibody (23742-1-AP)

    WB analysis of HeLa using 23742-1-AP (same clone as 23742-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 23742-1-AP (MNT antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 23742-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HeLa cells using MNT Polyclonal antibody (23742-1-AP)

    WB analysis of HeLa using 23742-1-AP (same clone as 23742-1-PBS)

    WB result of MNT antibody (23742-1-AP; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-MNT transfected HeLa cells. This data was developed using the same antibody clone with 23742-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HeLa cells using MNT Polyclonal antibody (23742-1-AP)

    IF Staining of HeLa using 23742-1-AP (same clone as 23742-1-PBS)

    Immunofluorescent analysis of (-20℃ Ethanol) fixed HeLa cells using 23742-1-AP (MNT antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 23742-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

23742-1-PBS bindet in WB, IF/ICC, Indirect ELISA MNT und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen MNT fusion protein Ag20666
Vollständiger Name MAX binding protein
Berechnetes Molekulargewicht 582 aa, 62 kDa
Beobachtetes Molekulargewicht 70 kDa
GenBank-ZugangsnummerBC117563
Gene symbol MNT
Gene ID (NCBI) 4335
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-affinitätsgereinigt
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Mnt (Max binding protein), also known as MAD6, ROX, bHLHd3 (class D basic helix-loop-helix protein 3) or MXD6, is a 582 amino acid nuclear protein that forms a complex with Max (Myc-associated factor X) to repress transcription. Mnt contains one basic helix-loop-helix (bHLH) domain and is encoded by a gene that maps to human chromosome 17p13.3. Chromosome 17 comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.