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MOG Rekombinanter Antikörper

MOG Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Hausschwein, human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250235E1

Kat-Nr. : 83063-6-PBS

Synonyme

MOGIG 2, Myelin-oligodendrocyte glycoprotein

Filter:
  • Western Blot (WB) analysis of various lysates using MOG Recombinant antibody (83063-6-RR)

    WB analysis using 83063-6-RR (same clone as 83063-6-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 83063-6-RR (MOG antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83063-6-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

83063-6-PBS bindet in WB, Indirect ELISA MOG und zeigt Reaktivität mit Hausschwein, human, Maus, Ratten

Getestete Reaktivität Hausschwein, human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen MOG fusion protein Eg2878
Vollständiger Name myelin oligodendrocyte glycoprotein
Berechnetes Molekulargewicht24 kDa
Beobachtetes Molekulargewicht 25-28 kDa
GenBank-ZugangsnummerN/A
Gene symbol MOG
Gene ID (NCBI) 4340
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Myelin/oligodendrocyte glycoprotein (MOG), a 23~28 kDa glycoprotein, a myelin antigen at the outer surface of the central nervous system (CNS) myelin sheath, which may trigger T-cell as well as B-cell responses. It therefore constitutes a pivotal target for autoimmune responses, which result in inflammation and also demyelination in the CNS. Its presence on the outer- most lamellae of mature CNS myelin and its late appearance during myelinogenesis suggest that it contributes to myelin maturation or maintenance. 10 isoforms of MOG produced by alternative splicing have been described, and heterodimers may be formed between the different isoforms. Defects in MOG are the cause of narcolepsy type 7 (NRCLP7), a neurological disabling sleep disorder characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Role of MOG in the pathogenesis of multiple sclerosis (MS) has been reported but remains to be clarified.