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MPC1 Polyklonaler Antikörper

MPC1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 30868-1-PBS

Synonyme

BRP44L, PNAS 115, HSPC040, CGI 129, Brain protein 44 like protein

Filter:
  • Western Blot (WB) analysis of various lysates using MPC1 Polyclonal antibody (30868-1-AP)

    WB analysis using 30868-1-AP (same clone as 30868-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30868-1-AP (BRP44L antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30868-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

30868-1-PBS bindet in WB, Indirect ELISA MPC1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen MPC1 fusion protein Ag28826
Vollständiger Name brain protein 44-like
Berechnetes Molekulargewicht 12 kDa
Beobachtetes Molekulargewicht12 kDa, 20-24 kDa
GenBank-ZugangsnummerBC000810
Gene symbol BRP44L
Gene ID (NCBI) 51660
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

MPC1, also known as BRP44L. BRP44L is predicted to be located in Mitochondrion inner membrane. The protein forms a heterodimer with MPC2, and the heterodimer is a more stable and dominant form (PMID:26253029, PMID:32403431). Mpc1 and Mpc2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane. Yeast and Drosophila mutants lacking MPC1 display impaired pyruvate metabolism, with an accumulation of upstream metabolites and a depletion of tricarboxylic acid cycle intermediates. Loss of yeast Mpc1 results in defective mitochondrial pyruvate uptake, and silencing of MPC1 or MPC2 in mammalian cells impairs pyruvate oxidation. A point mutation in MPC1 provides resistance to a known inhibitor of the mitochondrial pyruvate carrier (PMID: 22628558).The molecular weight of MPC1 is 12 kDa.