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MPP8 Rekombinanter Antikörper

MPP8 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242205B5

Kat-Nr. : 84719-4-PBS

Synonyme

MPHOSPH8, 242205B5, HSMPP8, M-phase phosphoprotein 8, Twa3

Filter:
  • Western Blot (WB) analysis of various lysates using MPP8 Recombinant antibody (84719-4-RR)

    WB analysis using 84719-4-RR (same clone as 84719-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84719-4-RR (MPP8 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84719-4-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

84719-4-PBS bindet in WB, Indirect ELISA MPP8 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen MPP8 fusion protein Ag10268
Vollständiger Name M-phase phosphoprotein 8
Berechnetes Molekulargewicht 860 aa, 97 kDa
Beobachtetes Molekulargewicht 97-105 kDa
GenBank-ZugangsnummerBC003542
Gene symbol MPP8
Gene ID (NCBI) 54737
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The M-phase phosphoprotein 8 (MPP8) was firstly identified to coimmunoprecipitate with the RanBPM-comprised large protein complex [PMID:19956676]. It also binds to methylated H3K9 and recruited the H3K9 methyltransferases GLP and ESET, as well as DNA methyltransferase 3A (DNMT3A) to the promoter of the E-cadherin gene, a key regulator of tumor cell growth and epithelial-to-mesenchymal transition (EMT) [PMID:18726070]. This binding event of MPP8-H3K9me modulates the expression of E-cadherin, a key regulator of cell-cell adhesion with implications in embryonic development, tissue morphogenesis and homeostasis , together with H3K9 methyltransferases GLP and ESET and DNA methyltransferase 3a (Dnmt3a)