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MRC2 Polyklonaler Antikörper

MRC2 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 21410-1-PBS

Synonyme

ENDO180, C-type mannose receptor 2, C-type lectin domain family 13 member E, CLEC13E, CD280

Filter:
  • Western Blot (WB) analysis of various lysates using MRC2 Polyclonal antibody (21410-1-AP)

    WB analysis using 21410-1-AP (same clone as 21410-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 21410-1-AP (MRC2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21410-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

21410-1-PBS bindet in WB, Indirect ELISA MRC2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen MRC2 fusion protein Ag15570
Vollständiger Name mannose receptor, C type 2
Berechnetes Molekulargewicht 1479 aa, 167 kDa
Beobachtetes Molekulargewicht170 kDa
GenBank-ZugangsnummerBC146647
Gene symbol MRC2
Gene ID (NCBI) 9902
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

C-type mannose receptor 2 (MRC2), also known as CD280, CLEC13E, ENDO180, KIAA0709, or UPARAP, is a type I transmembrane glycoprotein that belongs to the macrophage mannose receptor protein family (PMID: 10683150; 10636902; 9734811). It contains an N-terminal cysteine-rich domain, a fibronectin type II domain (FNII), eight C-type-lectin-like domains, and a transmembrane region followed by a small cytoplasmic domain (PMID: 34012764). MRC2 is a recycling endocytic receptor that functions in both these cellular activities by promoting cell migration and uptake of collagens for intracellular degradation (PMID: 17974964). MRC2 is expressed in several cells and organs including fibroblasts, endothelial cells, and macrophages. Altered MRC2 expression has been associated with the development and progression of different cancers, including head and neck squamous cell carcinoma, breast cancer, hepatocellular cancer, and prostate cancer (PMID: 36188226; 37666484; 17974964; 25162823).