MRC2 Rekombinanter Antikörper

MRC2 Rekombinant Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250494D5

Kat-Nr. : 86028-1-PBS

Synonyme

C type mannose receptor 2, CD280, CLEC13E, C-type lectin domain family 13 member E, C-type mannose receptor 2

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  WB analysis using 86028-1-RR (same clone as 86028-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86028-1-RR (MRC2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86028-1-PBS in a different storage buffer formulation.

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  IHC staining of human tonsillitis using 86028-1-RR (same clone as 86028-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 86028-1-RR (MRC2 antibody) at dilution of 1:800 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 86028-1-PBS in a different storage buffer formulation.

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  IHC staining of human tonsillitis using 86028-1-RR (same clone as 86028-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 86028-1-RR (MRC2 antibody) at dilution of 1:800 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 86028-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

86028-1-PBS bindet in WB, IHC, Indirect ELISA MRC2 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: MRC2 fusion protein Eg2653
• Vollständiger Name: mannose receptor, C type 2
• Berechnetes Molekulargewicht: 167 kDa
• Beobachtetes Molekulargewicht: 180 kDa
• GenBank-Zugangsnummer: NM_006039.5
• Gene symbol: MRC2
• Gene ID (NCBI): 9902
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

C-type mannose receptor 2 (MRC2), also known as CD280, CLEC13E, ENDO180, KIAA0709, or UPARAP, is a type I transmembrane glycoprotein that belongs to the macrophage mannose receptor protein family (PMID: 10683150; 10636902; 9734811). It contains an N-terminal cysteine-rich domain, a fibronectin type II domain (FNII), eight C-type-lectin-like domains, and a transmembrane region followed by a small cytoplasmic domain (PMID: 34012764). MRC2 is a recycling endocytic receptor that functions in both these cellular activities by promoting cell migration and uptake of collagens for intracellular degradation (PMID: 17974964). MRC2 is expressed in several cells and organs including fibroblasts, endothelial cells, and macrophages. Altered MRC2 expression has been associated with the development and progression of different cancers, including head and neck squamous cell carcinoma, breast cancer, hepatocellular cancer, and prostate cancer (PMID: 36188226; 37666484; 17974964; 25162823).