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MRE11A Monoklonaler Antikörper

MRE11A Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

1B12B2

Kat-Nr. : 67570-1-PBS

Synonyme

MRE11, 1B12B2, ATLD, Double-strand break repair protein MRE11, EC:3.1.-.-

Filter:
  • Western Blot (WB) analysis of various lysates using MRE11A Monoclonal antibody (67570-1-Ig)

    WB analysis using 67570-1-Ig (same clone as 67570-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67570-1-Ig (MRE11A antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67570-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

67570-1-PBS bindet in WB, Indirect ELISA MRE11A und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen MRE11A fusion protein Ag28847
Vollständiger Name MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Beobachtetes Molekulargewicht 81 kDa
GenBank-ZugangsnummerBC063458
Gene symbol MRE11A
Gene ID (NCBI) 4361
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Mre11 (meiotic recombination 11), also named as Mre11A, is a component of the MRN( MRE11/RAD50/NBS1) complex which is a versatile complex, playing a key role in the sensing, processing, and repair of DSBs. MRE11 possesses both endonuclease and 3'-5' exonuclease activity. It contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with CtIP (CtBP [C terminal binding protein] interacting protein) to initiate end resection. It's reported that MRE11 is over-expressed in breast cancers. (PMID:38128537; 22914783)