MRP1 Polyklonaler Antikörper

MRP1 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 27825-1-PBS

Synonyme

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  WB analysis using 27825-1-AP (same clone as 27825-1-PBS)

  37°C incubated HeLa cells were subjected to SDS PAGE followed by western blot with 27825-1-AP (MRP1 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27825-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 27825-1-AP (same clone as 27825-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 27825-1-AP (ABCC1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27825-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 27825-1-AP (same clone as 27825-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 27825-1-AP (ABCC1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27825-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

27825-1-PBS bindet in WB, IHC, Indirect ELISA MRP1 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: MRP1 fusion protein Ag27048
• Vollständiger Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 1
• Berechnetes Molekulargewicht: 172 kDa
• Beobachtetes Molekulargewicht: 180-190 kDa
• GenBank-Zugangsnummer: NM_004996
• Gene symbol: MRP1
• Gene ID (NCBI): 4363
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Multidrug resistant-associated protein 1 (MRP1, also known as ABCC1) is a member of the ATP-binding cassette (ABC) transporter protein superfamily, subfamily C. MRP1 is overexpressed in cancers and contributes to the occurrence of multidrug resistance (MDR). Expression of MRP1 has been considered as a negative marker for the outcome of chemotherapy. Recently MRP1 has been reported to play a crucial role in Aβ clearance at the blood-brain barrier.