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MRP1 Monoklonaler Antikörper

MRP1 Monoklonal Antikörper für WB, IF/ICC, ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

WB, IF/ICC, ELISA

Konjugation

Unkonjugiert

CloneNo.

1G4A2

Kat-Nr. : 67228-1-PBS

Synonyme

ABCC1, 1G4A2, MRP1/ABCC1

Filter:
  • Western Blot (WB) analysis of various lysates using MRP1 Monoclonal antibody (67228-1-Ig)

    WB analysis using 67228-1-Ig (same clone as 67228-1-PBS)

    Non-boil and boiled HepG2 and A549 cell lysates were subjected to SDS PAGE followed by western blot with 67228-1-Ig (ABCC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. Left panel was exposed for 20 sec. and right panel was exposed for 1 min. This data was developed using the same antibody clone with 67228-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of A549 cells using MRP1 Monoclonal antibody (67228-1-Ig)

    IF Staining of A549 using 67228-1-Ig (same clone as 67228-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed A549 cells using MRP1 antibody (67228-1-Ig, Clone: 1G4A2 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67228-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

67228-1-PBS bindet in WB, IF/ICC, ELISA MRP1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen MRP1 fusion protein Ag27048
Vollständiger Name ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Berechnetes Molekulargewicht 172 kDa
Beobachtetes Molekulargewicht 180-190 kDa
GenBank-ZugangsnummerNM_004996
Gene symbol MRP1
Gene ID (NCBI) 4363
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Multidrug resistant-associated protein 1 (MRP1; ABCC1) is a member of the ATP-binding cassette (ABC) transporter protein superfamily, subfamily C. MRP1 is overexpressed in cancers and contributes to the occurrence of multidrug resistance (MDR). Expression of MRP1 has been considered as a negative marker for the outcome of chemotherapy. Recently MRP1 has been reported to play a crucial role in Aβ clearance at the blood-brain barrier.