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MRP2 Polyklonaler Antikörper

MRP2 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

Konjugation

Unkonjugiert

Kat-Nr. : 24893-1-PBS

Synonyme

ABCC2, ABCC 2, ATP-binding cassette sub-family C member 2, CMOAT, CMOAT1

Filter:
  • Western Blot (WB) analysis of HepG2 cells using MRP2 Polyclonal antibody (24893-1-AP)

    WB analysis of HepG2 using 24893-1-AP (same clone as 24893-1-PBS)

    HepG2 cells were subjected to SDS PAGE followed by western blot with 24893-1-AP (MRP2 antibody at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24893-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human small intestine tissue using MRP2 Polyclonal antibody (24893-1-AP)

    IHC staining of human small intestine using 24893-1-AP (same clone as 24893-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 24893-1-AP (MRP2 antibody at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 24893-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human small intestine tissue using MRP2 Polyclonal antibody (24893-1-AP)

    IHC staining of human small intestine using 24893-1-AP (same clone as 24893-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 24893-1-AP (MRP2 antibody at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 24893-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

24893-1-PBS bindet in MRP2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen MRP2 fusion protein Ag18694
Vollständiger Name ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Berechnetes Molekulargewicht 1545 aa, 174 kDa
Beobachtetes Molekulargewicht 190-250 kDa
GenBank-ZugangsnummerBC136419
Gene symbol ABCC2
Gene ID (NCBI) 1244
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Multi-drug resistance protein 2 (MRP2), also known as ABCC2, is an ATP binding cassette (ABC) transporter responsible for biliary excretion of xenobiotics, endobiotics, and their metabolites. Deficiency in ABCC2 results in the clinical disorder Dubin-Johnson syndrome. MRP2 is found to be expressed in a variety of human cancers, and is associated with resistance of tumor cells to various anticancer drugs including cisplatin. The predicted molecular weight of MRP2 is 174 kDa, while mature MRP2 usually has a slower migration around 190-250 kDa due to the glycosylation. (16434545, 18834541, 23045960)