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Mesothelin Rekombinanter Antikörper

Mesothelin Rekombinant Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

CloneNo.

240795B12

Kat-Nr. : 83744-6-PBS

Synonyme

MSLN, MPF, Mesothelin, cleaved form, Megakaryocyte-potentiating factor, CAK1 antigen

Filter:
  • Western Blot (WB) analysis of various lysates using Mesothelin Recombinant antibody (83744-6-RR)

    WB analysis using 83744-6-RR (same clone as 83744-6-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 83744-6-RR (MSLN antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83744-6-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

83744-6-PBS bindet in WB, ELISA Mesothelin und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Fusionsprotein
Vollständiger Name mesothelin
Berechnetes Molekulargewicht69KD
Beobachtetes Molekulargewicht40 kDa, 69 kDa
GenBank-ZugangsnummerNM_005823
Gene symbol MSLN
Gene ID (NCBI) 10232
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Mesothelin (MSLN) is a 40kDa GPI-anchored surface glycoprotein that is expressed on pleural and peritoneal mesothelial cells, but not in other non-neoplastic tissues. The mesothelin gene encodes a 69-71kDa precursor protein that is processed to a 40kDa membrane-bound protein termed mesothelin and a 31kDa shed fragment called megakaryocyte-potentiating factor (MPF) that is released from the cell. Mesothelin is a tumor differentiation antigen present at low levels on a restricted set of normal adult tissues (e.g. mesothelium), and is expressed at high levels in mesotheliomas, as well as ovarian, pancreatic, and lung cancers. Mesothelin may be a new target for immunotherapy (PMID: 20922056, 18691948, 15217923).