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MTUS1 Polyklonaler Antikörper

MTUS1 Polyklonal Antikörper für WB,ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB,ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 18791-1-AP

Synonyme

AT2 receptor binding protein, ATBP, ATIP, GK1, KIAA1288, MP44, MTSG1, MTUS1

Galerie der Validierungsdaten

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  • Western Blot (WB) analysis of human skeletal muscle tissue using MTUS1 Polyclonal antibody (18791-1-AP)

    WB analysis of human skeletal muscle using 18791-1-AP

    human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 18791-1-AP (MTUS1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

  • Western Blot (WB) analysis of mouse uterus tissue using MTUS1 Polyclonal antibody (18791-1-AP)

    WB analysis of mouse uterus using 18791-1-AP

    mouse uterus tissue were subjected to SDS PAGE followed by western blot with 18791-1-AP (MTUS1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

  • Western Blot (WB) analysis of human skeletal muscle tissue using MTUS1 Polyclonal antibody (18791-1-AP)

    WB analysis of human skeletal muscle using 18791-1-AP

    human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 18791-1-AP (MTUS1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

Geprüfte Anwendungen

Erfolgreiche Detektion in WBhumanes Skelettmuskelgewebe, Maus-Uterusgewebe

Empfohlene Verdünnung

AnwendungVerdünnung
Western Blot (WB)WB : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

18791-1-AP bindet in WB,ELISA MTUS1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen MTUS1 fusion protein Ag5605
Vollständiger Name mitochondrial tumor suppressor 1
Berechnetes Molekulargewicht 51 kDa, 141 kDa
Beobachtetes Molekulargewicht 120 kDa, 180 kDa
GenBank-ZugangsnummerBC033842
Gene symbol MTUS1
Gene ID (NCBI) 57509
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

MTUS1, also named as ATBP, ATIP, GK1, KIAA1288 and MTSG1, Belongs to the MTUS1 family. It cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. MTUS1 may be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. MTUS1 up-regulation during cellular transition from proliferation to quiescence and differentiation. It is a potential tumor suppressor gene located at chromosome 8p21.3.22, near marker D8S254. According to the functional data and intracellular localization, MTUS1 also named as mitochondrial tumor suppressor gene 1 (MTSG1). One main feature common to all ATIP members is the presence of a large C-terminal coiled-coil domain that allows homo- and hetero-dimerization of these proteins. (PMID:12692079, 15123706) The antibody can recognize all the isoforms except isoform 5 (85-90kd). The antibody tested HomoDimer isoforms (110-120/180kd) in Human skeletal muscle.