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MUC20 Monoklonaler Antikörper

MUC20 Monoklonal Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Maus / IgG3

Getestete Reaktivität

human, Hund

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

1G9B2

Kat-Nr. : 68714-1-PBS

Synonyme

UNQ2782/PRO7170, Mucin-20, MUC-20, MUC 20, KIAA1359

Filter:
  • Western Blot (WB) analysis of various lysates using MUC20 Monoclonal antibody (68714-1-Ig)

    WB analysis using 68714-1-Ig (same clone as 68714-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68714-1-Ig (MUC20 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68714-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HepG2 cells using MUC20 Monoclonal antibody (68714-1-Ig)

    IF Staining of HepG2 using 68714-1-Ig (same clone as 68714-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using MUC20 antibody (68714-1-Ig, Clone: 1G9B2 ) at dilution of 1:800 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1). This data was developed using the same antibody clone with 68714-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

68714-1-PBS bindet in WB, IF/ICC, Indirect ELISA MUC20 und zeigt Reaktivität mit human, Hund

Getestete Reaktivität human, Hund
Wirt / Isotyp Maus / IgG3
Klonalität Monoklonal
Typ Antikörper
Immunogen MUC20 fusion protein Ag31840
Vollständiger Name mucin 20, cell surface associated
Berechnetes Molekulargewicht 55 kDa, 71 kDa
Beobachtetes Molekulargewicht 70 kDa
GenBank-ZugangsnummerBC029267
Gene symbol MUC20
Gene ID (NCBI) 200958
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

MUC20 contains serine, threonine, and proline-rich repeats in its extracellular domain and is likely to be extensively O-glycosylated. MUC20 blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway and inhibiting HGF-induced proliferation of MMP1 and MMP9 expression (PMID: 15314156). MUC20 is highly expressed in the kidney and localized in the proximal tubules but not in the glomerulus or distal tubules(PMID: 14565953). MUC20 was detected in most of the male urogenital tract epithelia, except for epididymis(PMID: 16997931). The expression of MUC20 is up-regulated in the kidneys of patients with immunoglobulin A nephropathy, in an animal model of lupus nephritis, and in mice with acute renal injury caused by cisplatin administration or unilateral ureteral obstruction(PMID: 14565953).