MXRA5 Polyklonaler Antikörper

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• KD/KO Validated

MXRA5 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 25472-1-PBS

Synonyme

Adlican

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  WB analysis using 25472-1-AP (same clone as 25472-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 25472-1-AP (MXRA5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human kidney using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human colon cancer using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human colon cancer using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human kidney using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

25472-1-PBS bindet in WB, IHC, Indirect ELISA MXRA5 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: matrix-remodelling associated 5
• Berechnetes Molekulargewicht: 312 kDa
• Beobachtetes Molekulargewicht: 163 kDa, 312 kDa
• GenBank-Zugangsnummer: NM_015419
• Gene symbol: MXRA5
• Gene ID (NCBI): 25878
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

MXRA5, or adlican, is an adhesion proteoglycan involved in extracellular matrix (ECM) remodeling and cell-cell adhesion (PMID: 22696596). In kidney, MXRA5 has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli (PMID: 27599751). MXRA5 was identified as a novel biomarker in colorectal cancer, mainly located in the cytoplasm of CRC cells (PMID:23420087). Exome sequencing identified MXRA5 as a novel cancer gene mutated in non-small cell lung carcinoma (PMID: 22696596). MXRA5 was detected 163 kDa in human proximal tubular cells (PMID:27599751).