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MYB/c-Myb Monoklonaler Antikörper

MYB/c-Myb Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

Hausschwein, human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

2A12C2

Kat-Nr. : 60550-1-PBS

Synonyme

MYB, c-Myb, Transcriptional activator Myb, Proto-oncogene c-Myb, Proto oncogene c Myb

Filter:
  • Western Blot (WB) analysis of various lysates using MYB/c-Myb Monoclonal antibody (60550-1-Ig)

    WB analysis using 60550-1-Ig (same clone as 60550-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 60550-1-Ig (MYB antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60550-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

60550-1-PBS bindet in WB, Indirect ELISA MYB/c-Myb und zeigt Reaktivität mit Hausschwein, human, Maus

Getestete Reaktivität Hausschwein, human, Maus
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen MYB/c-Myb fusion protein Ag34185
Vollständiger Name v-myb myeloblastosis viral oncogene homolog (avian)
Berechnetes Molekulargewicht 640 aa, 72 kDa
Beobachtetes Molekulargewicht40-50 kDa, 72-80 kDa
GenBank-ZugangsnummerBC064955
Gene symbol c-Myb
Gene ID (NCBI) 4602
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The MYB protein is a transcription factor that plays a key role in regulating the proliferation/differentiation of progenitor cells in bone marrow, colonic crypts, and neurogenic niches [PMID:18574464]. It is involved in the regulation of epithelial-to-mesenchymal transition (EMT) and invasion in neuroblastoma, colon carcinoma, and embryonic kidney cells through the upregulation of the transcription repressor Slug [PMID:20622260]. It also a DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3', and plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. MYB exists some isoforms with MV 85, 75, 72, 68, 63 and 40 kDa.