MYC Polyklonaler Antikörper

MYC Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IP, IHC, IF, CoIP, ELISA

Konjugation

Unkonjugiert

Publikationen

25

Kat-Nr. : 10059-1-AP

Synonyme

c Myc, Myc proto oncogene protein

---

Galerie der Validierungsdaten

• 

---

Geprüfte Anwendungen

Empfohlene Verdünnung

Anwendung	Verdünnung
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• WB: See 22 publications below
• IHC: See 4 publications below
• IF: See 1 publications below
• IP: See 3 publications below
• CoIP: See 2 publications below

Produktinformation

10059-1-AP bindet in WB, IP, IHC, IF, CoIP, ELISA MYC und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: v-myc myelocytomatosis viral oncogene homolog (avian)
• Berechnetes Molekulargewicht: 48 aa, 8 kDa
• GenBank-Zugangsnummer: BC000917
• Gene symbol: MYC
• Gene ID (NCBI): 4609
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

MYC contains one basic helix-loop-helix (bHLH) domain. This protein is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. It seems to activate the transcription of growth-related genes. It binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. This antibody is a rabbit polyclonal antibody raised against recombinant protein of human MYC.The 50kDa band recognized by antibody is the native form of MYC, while the other bands, between 60-70kDa, are the phosphorylated form of MYC [PMID: 12189186]

Publikationen

Species	Application	Title
human	WB	Adv Sci (Weinh); NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition; Authors - Tie-Gang Meng
human	WB	Int J Biol Sci; CTSG Suppresses Colorectal Cancer Progression through Negative Regulation of Akt/mTOR/Bcl2 Signaling Pathway; Authors - Shixin Chan
human	WB,IP	Oncogene; N4-acetylcytidine modification of lncRNA CTC-490G23.2 promotes cancer metastasis through interacting with PTBP1 to increase CD44 alternative splicing; Authors - Xiao-Mei Yu
mouse	WB	Bioeng Transl Med; Identification of PIK3CG as a hub in septic myocardial injury using network pharmacology and weighted gene co-expression network analysis; Authors - Qiong Liu
	WB	Plant Physiol; Lysine malonylation of DgnsLIPID TRANSFER PROTEIN1 at the K81 site improves cold resistance in chrysanthemum; Authors - Xiaoqin Liao
human	CoIP	Mol Ther Nucleic Acids; miR21 modulates the Hippo signaling pathway via interference with PP2A Bβ to inhibit trophoblast invasion and cause preeclampsia; Authors - Mingyu Hu