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Mesothelin Rekombinanter Antikörper

Mesothelin Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

243099D4

Kat-Nr. : 85774-4-PBS

Synonyme

Megakaryocyte-potentiating factor, Mes, Mesothelin, cleaved form, Mpf, Msln

Filter:
  • Western Blot (WB) analysis of mouse serum using Mesothelin Recombinant antibody (85774-4-RR)

    WB analysis of mouse serum using 85774-4-RR (same clone as 85774-4-PBS)

    mouse serum were subjected to SDS PAGE followed by western blot with 85774-4-RR (Msln antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85774-4-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

85774-4-PBS bindet in WB, Indirect ELISA Mesothelin und zeigt Reaktivität mit Maus

Getestete Reaktivität Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Mesothelin fusion protein Eg2864
Vollständiger Name mesothelin
Berechnetes Molekulargewicht69 kDa
Beobachtetes Molekulargewicht46 kDa
GenBank-ZugangsnummerNM_018857.1
Gene symbol Msln
Gene ID (NCBI) 56047
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Mesothelin (MSLN) is a cell surface glycoprotein that was discovered in 1992 by Kai Chang, Ira Pastan, and Mark Willingham at the National Cancer Institute in Bethesda, MD. It is synthesized as a 69-kDa precursor protein, which is cleaved to form two proteins: a membrane-bound MSLN and a soluble megakaryocyte potentiating factor (MPF). MSLN is overexpressed in various tumor types, including mesothelioma, ovarian cancer, pancreatic adenocarcinoma, gastric cancer, and triple-negative breast cancer (TNBC). However, it is expressed at low levels in normal tissues, primarily on the mesothelial cells lining the pleura, pericardium, and peritoneum. (PMID: 37869242)