N-cadherin Monoklonaler Antikörper
N-cadherin Monoklonal Antikörper für WB, IHC, IF-P, Indirect ELISA
Wirt / Isotyp
Maus / IgG2b
Getestete Reaktivität
Hausschwein, human, Kaninchen, Maus, Ratte
Anwendung
WB, IHC, IF-P, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
2G7C2
Kat-Nr. : 68532-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
68532-1-PBS bindet in WB, IHC, IF-P, Indirect ELISA N-cadherin und zeigt Reaktivität mit Hausschwein, human, Kaninchen, Maus, Ratten
Getestete Reaktivität | Hausschwein, human, Kaninchen, Maus, Ratte |
Wirt / Isotyp | Maus / IgG2b |
Klonalität | Monoklonal |
Typ | Antikörper |
Immunogen | Rekombinantes Protein |
Vollständiger Name | cadherin 2, type 1, N-cadherin (neuronal) |
Berechnetes Molekulargewicht | 100 kDa |
Beobachtetes Molekulargewicht | 130 kDa |
GenBank-Zugangsnummer | NM_001792.4 |
Gene symbol | N-cadherin |
Gene ID (NCBI) | 1000 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein-A-Reinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. N-cadherin (neural cadherin), also known as CDH2 (cadherin 2), is a 130-kDa transmembrane protein and a classical member of the cadherin superfamily which also include E-, P-, R-, and B-cadherins. Expression of N-cadherin has been reported on various cell types including neurons, endothelial cells and cardiac myocytes (PMID: 11282032; 9508779; 8125202). N-cadherin has functions in early brain morphogenesis, synaptogenesis and synaptic plasticity (PMID: 23321619). The N-cadherin ectodomain can be cleaved, leading to the generation of a 90 kD N-terminal fragment (PMID: 16998833; 17028923).