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N-cadherin Rekombinanter Antikörper
N-cadherin Rekombinant Antikörper für WB, IHC, IF/ICC, Indirect ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human
Anwendung
WB, IHC, IF/ICC, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
230259H5
Kat-Nr. : 82968-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
82968-1-PBS bindet in WB, IHC, IF/ICC, Indirect ELISA N-cadherin und zeigt Reaktivität mit human
Getestete Reaktivität | human |
Wirt / Isotyp | Kaninchen / IgG |
Klonalität | Rekombinant |
Typ | Antikörper |
Immunogen | N-cadherin fusion protein Eg0701 |
Vollständiger Name | cadherin 2, type 1, N-cadherin (neuronal) |
Berechnetes Molekulargewicht | 100 kDa |
Beobachtetes Molekulargewicht | 130 kDa |
GenBank-Zugangsnummer | NM_001792.4 |
Gene symbol | N-cadherin |
Gene ID (NCBI) | 1000 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein-A-Reinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. N-cadherin (neural cadherin), also known as CDH2 (cadherin 2), is a 130-kDa transmembrane protein and a classical member of the cadherin superfamily which also includes E-, P-, R-, and B-cadherins. Expression of N-cadherin has been reported on various cell types including neurons, endothelial cells and cardiac myocytes (PMID: 11282032; 9508779; 8125202). N-cadherin has functions in early brain morphogenesis, synaptogenesis and synaptic plasticity (PMID: 23321619). The N-cadherin ectodomain can be cleaved, leading to the generation of a 90 kD N-terminal fragment (PMID: 16998833; 17028923).