NCAM1/CD56 Rekombinanter Antikörper
NCAM1/CD56 Rekombinant Antikörper für Cytometric bead array, Indirect ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human
Anwendung
Cytometric bead array, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
240078B9
Kat-Nr. : 83365-3-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
83365-3-PBS bindet in Cytometric bead array, Indirect ELISA NCAM1/CD56 und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| Wirt / Isotyp | Kaninchen / IgG |
| Klonalität | Rekombinant |
| Typ | Antikörper |
| Immunogen | NCAM1/CD56 fusion protein Eg31816 |
| Vollständiger Name | neural cell adhesion molecule 1 |
| Berechnetes Molekulargewicht | 95 kDa |
| GenBank-Zugangsnummer | BC047244 |
| Gene symbol | NCAM1 |
| Gene ID (NCBI) | 4684 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Protein-A-Reinigung |
| Lagerungspuffer | PBS only |
| Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Neural cell adhesion molecule 1 (NCAM1, also known as CD56) is a cell adhesion glycoprotein of the immunoglobulin (Ig) superfamily. It is a multifunction protein involved in synaptic plasticity, neurodevelopment, and neurogenesis. NCAM1 is expressed on human neurons, glial cells, skeletal muscle cells, NK cells and a subset of T cells, and the expression is observed in a wide variety of human tumors, including myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, and NK/T cell lymphomas. Three major isoforms of NCAM1, with molecular masses of 120, 140, and 180 kDa, are generated by alternative splicing of mRNA (PMID: 9696812). The glycosylphosphatidylinositol (GPI)-anchored NCAM120 and the transmembrane NCAM140 and NCAM180 consist of five Ig-like domains and two fibronection-type III repeats (FNIII). All three forms can be posttranslationally modified by addition of polysialic acid (PSA) (PMID: 14976519). Several other isofroms have also been described (PMID: 1856291).
