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NCDN Rekombinanter Antikörper

NCDN Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

243146E2

Kat-Nr. : 85730-1-PBS

Synonyme

Neurochondrin, KIAA0607, NEDIES

Filter:
  • Western Blot (WB) analysis of various lysates using NCDN Recombinant antibody (85730-1-RR)

    WB analysis using 85730-1-RR (same clone as 85730-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85730-1-RR (NCDN antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85730-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85730-1-RR

    Affinity and Kinetic Characterization of 85730-1-RR

    Biolayer interferometry (BLl) kinetic assays of 85730-1-RR against Human NCDN were performed. The affinity constant is 1.35 nM.

Geprüfte Anwendungen

Produktinformation

85730-1-PBS bindet in WB, Indirect ELISA NCDN und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen NCDN fusion protein Ag3859
Vollständiger Name neurochondrin
Berechnetes Molekulargewicht 729 aa, 79 kDa
Beobachtetes Molekulargewicht75-79 kDa
GenBank-ZugangsnummerBC024592
Gene symbol Neurochondrin
Gene ID (NCBI) 23154
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

NCDN protein (Neurochondrin) is a highly conserved 79 kDa adaptor protein, which was first discovered in 1997 and mainly expressed in the nervous system. NCDN protein plays an important role in neuronal differentiation, formation and maintenance of dendritic spines. It is involved in the development of synapses, neuronal differentiation and signal transduction, and maintains cell polarity by regulating dendritic morphogenesis and neural signal pathway. Recent studies have found that NCDN protein is expressed not only in neurons, but also in myeloid cells (such as neutrophils), and plays a role as a negative regulator of innate immunity. Mice lacking NCDN in myeloid cells are more immune to bacterial infection because of the increased reactivity of neutrophils (PMID: 37503670). The molecular weight of NCDN is 78 kDa.