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NCOA1/SRC-1 Polyklonaler Antikörper

NCOA1/SRC-1 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 21952-1-PBS

Synonyme

NCOA1, SRC 1, bHLHe42, BHLHE74, Class E basic helix-loop-helix protein 74

Filter:
  • Western Blot (WB) analysis of various lysates using NCOA1/SRC-1 Polyclonal antibody (21952-1-AP)

    WB analysis using 21952-1-AP (same clone as 21952-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 21952-1-AP (NCOA1/SRC-1 antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21952-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse brain tissue using NCOA1/SRC-1 Polyclonal antibody (21952-1-AP)

    IHC staining of mouse brain using 21952-1-AP (same clone as 21952-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 21952-1-AP (NCOA1/SRC-1 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21952-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

21952-1-PBS bindet in WB, IHC, Indirect ELISA NCOA1/SRC-1 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen NCOA1/SRC-1 fusion protein Ag16603
Vollständiger Name nuclear receptor coactivator 1
Berechnetes Molekulargewicht 1441 aa, 157 kDa
Beobachtetes Molekulargewicht 140-160 kDa
GenBank-ZugangsnummerBC111533
Gene symbol SRC 1/NCOA1
Gene ID (NCBI) 8648
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-affinitätsgereinigt
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Nuclear receptor coactivator 1, also named SRC-1, directly binds nuclear receptors and stimulates transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR, and ER), retinoids (RXRs), thyroid hormone (TRs), and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B, and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via the remodeling of chromatin, and possibly act by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.