- Featured Product
- KD/KO Validated
NFATC1 Monoklonaler Antikörper
NFATC1 Monoklonal Antikörper für
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
human
Anwendung
Konjugation
CoraLite®594 Fluorescent Dye
CloneNo.
1E1B10
Kat-Nr. : CL594-66963
Synonyme
Geprüfte Anwendungen
Produktinformation
CL594-66963 bindet in NFATC1 und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| Wirt / Isotyp | Maus / IgG1 |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | NFATC1 fusion protein Ag13014 |
| Vollständiger Name | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 |
| Berechnetes Molekulargewicht | 716aa,78 kDa; 943aa,101 kDa |
| Beobachtetes Molekulargewicht | 101 kDa |
| GenBank-Zugangsnummer | BC104753 |
| Gene symbol | NFATC1 |
| Gene ID (NCBI) | 4772 |
| Konjugation | CoraLite®594 Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 588 nm / 604 nm |
| Form | Liquid |
| Reinigungsmethode | Protein-G-Reinigung |
| Lagerungspuffer | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA |
| Lagerungsbedingungen | Bei -20°C lagern. Vor Licht schützen. Nach dem Versand ein Jahr stabil. Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
NFATc1(nuclear factor-activated T cells c1) is one of the transcription factors family consisting 5 members which were considered as a regulator of T-cell activation. In immune cell, NFATc1 is located in the cytoplasm in a hyperphosphorylated state and translocates into the nucleus upon cell stimulation via dephosphorylation(PMID:28327458). One paper observed that ectopic expression and nuclear accumulation of NFATc1 in more than 60% of human pancreatic cancers (PMID:25623042). Several alternative splicing transcript variants encoding different isoforms have been identified for this gene. And different isoforms of this protein may regulate different cytokine gene expression. NFATc1 is a main transcriptional activator for cytokine genes in activated lymphoid cells. Also some studies demonstrated that NFATc1 plays the role of a master transcription regulator of osteoclast differentiation (PMID:25489571).
