NK1.1 (CD161) Monoklonaler Antikörper

NK1.1 (CD161) Monoklonal Antikörper für FC

Wirt / Isotyp

Maus / IgG2a, kappa

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

CoraLite®594 Fluorescent Dye

CloneNo.

PK136

Kat-Nr. : CL594-65138

Synonyme

Klrb1a, CD161a, PK136, Nkrp1a, NK1.1

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  FC experiment of C57BL/6 mouse splenocytes using CL594-65138

  1X10^6 C57BL/6 mouse splenocytes were surface stained with 0.5 ug CoraLite®594 Anti-Mouse NK1.1 (CD161) (CL594-65138, Clone: PK136) or 0.5 ug CoraLite®594 Mouse IgG2a Isotype Control (C1.18.4) (CL594-65208, Clone: C1.18.4), and 0.5 ug APC Anti-Mouse CD49b (DX5) (APC-65065, Clone: DX5). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: Maus-Splenozyten

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

CL594-65138 bindet in FC NK1.1 (CD161) und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Maus / IgG2a, kappa
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: NK-1+-Zellen aus Mausmilz und -knochenmark
• Vollständiger Name: killer cell lectin-like receptor subfamily B member 1A
• GenBank-Zugangsnummer: BC120707
• Gene symbol: NK1.1
• Gene ID (NCBI): 17057
• Konjugation: CoraLite®594 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 588 nm / 604 nm
• Form: Liquid
• Reinigungsmethode: Affinitätsreinigung
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

NK1.1 (CD161), also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665).