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NKX3-1 Rekombinanter Antikörper

NKX3-1 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250402B8

Kat-Nr. : 86085-1-PBS

Synonyme

BAPX2, Homeobox protein NK-3 homolog A, Homeobox protein Nkx 3.1, Homeobox protein Nkx-3.1, NK3 homeobox 1

Filter:
  • Western Blot (WB) analysis of LNCaP cells using NKX3-1 Recombinant monoclonal antibody (86085-1-RR)

    WB analysis of LNCaP using 86085-1-RR (same clone as 86085-1-PBS)

    LNCaP cells were subjected to SDS PAGE followed by western blot with 86085-1-RR (NKX3-1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86085-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86085-1-RR

    Affinity and Kinetic Characterization of 86085-1-RR

    Biolayer interferometry (BLl) kinetic assays of 86085-1-RR against Human NKX3-1 were performed. The affinity constant is 0.411 nM.

Geprüfte Anwendungen

Produktinformation

86085-1-PBS bindet in WB, Indirect ELISA NKX3-1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen NKX3-1 fusion protein Ag4070
Vollständiger Name NK3 homeobox 1
Berechnetes Molekulargewicht 234 aa, 26 kDa
Beobachtetes Molekulargewicht34-38 kDa
GenBank-ZugangsnummerBC074864
Gene symbol NKX3-1
Gene ID (NCBI) 4824
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

NKX3-1, also named as NKX3.1 and NKX3A, belongs to the NK-3 homeobox family. It is a transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. NKX3-1 plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. It act as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells(PMID:19462257). The calcualted molecular weight of NKX3-1 is 26 kDa, but modified NKX3-1 is about 32-35 kDa. (PMID: 18597829)