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NKp46/NCR1 Rekombinanter Antikörper

NKp46/NCR1 Rekombinant Antikörper für IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242549C5

Kat-Nr. : 85021-4-PBS

Synonyme

NCR 1, Natural killer cell p46-related protein, LY94, hNKp46, CD335

Filter:
  • Immunofluorescence (IF) / fluorescent staining of NK-92 cells using NKp46/NCR1 Recombinant antibody (85021-4-RR)

    IF Staining of NK-92 using 85021-4-RR (same clone as 85021-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed NK-92 cells using NKp46/NCR1/CD335 antibody (85021-4-RR, Clone: 242549C5 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 85021-4-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

85021-4-PBS bindet in IF/ICC, Indirect ELISA NKp46/NCR1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name natural cytotoxicity triggering receptor 1
Berechnetes Molekulargewicht34kDa
Gene symbol NCR1
Gene ID (NCBI) 9437
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

NKp46, also known as natural cytotoxicity triggering receptor 1 (NCR1), is a type I transmembrane protein belonging to the immunoglobulin superfamily. NKp46 is a key activating receptor expressed on natural killer (NK) cells. It plays a key role in the innate immune response by recognizing and binding to viral hemagglutinins and other ligands on infected or tumor cells. NKp46 mediates cytotoxicity and cytokine production upon engagement with its ligands, contributing to the elimination of infected or malignant cells. Its expression and function are tightly regulated, and dysregulation of NKp46 has been implicated in various diseases, including viral infections, cancer, and autoimmune disorders. (PMID: 11234016; 29329948; 9730896; 9314561).