NKp46/NCR1 Rekombinanter Antikörper

NKp46/NCR1 Rekombinant Antikörper für IF/ICC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IF/ICC, ELISA

Konjugation

Unkonjugiert

CloneNo.

242549C5

Kat-Nr. : 85021-4-RR

Synonyme

NCR 1, Natural killer cell p46-related protein, LY94, hNKp46, CD335

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  IF Staining of NK-92 using 85021-4-RR

  Immunofluorescent analysis of (4% PFA) fixed NK-92 cells using NKp46/NCR1/CD335 antibody (85021-4-RR, Clone: 242549C5 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2).

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IF/ICC: NK-92 cells

Empfohlene Verdünnung

• Immunfluoreszenz (IF)/ICC: IF/ICC : 1:200-1:800

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

85021-4-RR bindet in IF/ICC, ELISA NKp46/NCR1 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: natural cytotoxicity triggering receptor 1
• Berechnetes Molekulargewicht: 34kDa
• Gene symbol: NCR1
• Gene ID (NCBI): 9437
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

NKp46, also known as natural cytotoxicity triggering receptor 1 (NCR1), is a type I transmembrane protein belonging to the immunoglobulin superfamily. NKp46 is a key activating receptor expressed on natural killer (NK) cells. It plays a key role in the innate immune response by recognizing and binding to viral hemagglutinins and other ligands on infected or tumor cells. NKp46 mediates cytotoxicity and cytokine production upon engagement with its ligands, contributing to the elimination of infected or malignant cells. Its expression and function are tightly regulated, and dysregulation of NKp46 has been implicated in various diseases, including viral infections, cancer, and autoimmune disorders. (PMID: 11234016; 29329948; 9730896; 9314561).