NKp46/NCR1 Rekombinanter Antikörper

NKp46/NCR1 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241804A12

Kat-Nr. : 98198-1-PBS

Synonyme

Ncr1, mNKp46, Lymphocyte antigen 94, Ly94, CD335

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  FC experiment of mouse splenocytes using 98198-1-RR (same clone as 98198-1-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse NKp46/NCR1 Rabbit Recombinant Antibody (98198-1-RR, Clone: 241804A12) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Mouse CD49b. Cells were not fixed. This data was developed using the same antibody clone with 98198-1-PBS in a different storage buffer formulation.

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  FC experiment of mouse splenocytes using 98198-1-RR (same clone as 98198-1-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse NKp46/NCR1 Rabbit Recombinant Antibody (98198-1-RR, Clone: 241804A12)(red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98198-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98198-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98198-1-RR against Mouse NKp46/NCR1 were performed. The affinity constant is below 1 pM.

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Geprüfte Anwendungen

Produktinformation

98198-1-PBS bindet in FC NKp46/NCR1 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: natural cytotoxicity triggering receptor 1
• Berechnetes Molekulargewicht: 37kDa
• GenBank-Zugangsnummer: NM_010746.3
• Gene symbol: NKp46/NCR1
• Gene ID (NCBI): 17086
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

NKp46, also known as NCR1 or CD335, is an Ig-like superfamily cell surface receptor that is highly conserved in mammals (PMID: 22021440). NKp46 is a type I transmembrane glycoprotein consisting of two extracellular Ig-like domains, a transmembrane domain, and an intracellular tail (PMID: 9730896). It is expressed on NK cells, rare T-cell subsets and a mucosal population of NKp46+ innate lymphoid cells (PMID: 9730896; 22021440). NKp46 is the major triggering receptor involved in the natural cytotoxicity (PMID: 10359120; 10092106; 15356098).