NKp46/NCR1 Rekombinanter Antikörper

NKp46/NCR1 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241804A12

Kat-Nr. : 98198-1-RR

Synonyme

Ncr1, mNKp46, Lymphocyte antigen 94, Ly94, CD335

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  FC experiment of mouse splenocytes using 98198-1-RR

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse NKp46/NCR1 Rabbit Recombinant Antibody (98198-1-RR, Clone: 241804A12) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Mouse CD49b. Cells were not fixed.

• 

  FC experiment of mouse splenocytes using 98198-1-RR

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse NKp46/NCR1 Rabbit Recombinant Antibody (98198-1-RR, Clone: 241804A12)(red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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  Affinity and Kinetic Characterization of 98198-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98198-1-RR against Mouse NKp46/NCR1 were performed. The affinity constant is below 1 pM.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: Maus-Splenozyten

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

98198-1-RR bindet in FC NKp46/NCR1 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: natural cytotoxicity triggering receptor 1
• Berechnetes Molekulargewicht: 37kDa
• GenBank-Zugangsnummer: NM_010746.3
• Gene symbol: NKp46/NCR1
• Gene ID (NCBI): 17086
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2 - 8°C. Stable for one year after shipment.

Hintergrundinformationen

NKp46, also known as NCR1 or CD335, is an Ig-like superfamily cell surface receptor that is highly conserved in mammals (PMID: 22021440). NKp46 is a type I transmembrane glycoprotein consisting of two extracellular Ig-like domains, a transmembrane domain, and an intracellular tail (PMID: 9730896). It is expressed on NK cells, rare T-cell subsets and a mucosal population of NKp46+ innate lymphoid cells (PMID: 9730896; 22021440). NKp46 is the major triggering receptor involved in the natural cytotoxicity (PMID: 10359120; 10092106; 15356098).