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NLRP12 Rekombinanter Antikörper

NLRP12 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241838E11

Kat-Nr. : 83123-6-PBS

Synonyme

PAN6, NALP12, NACHT, LRR and PYD domains-containing protein 12, Monarch-1, Monarch 1

Filter:
  • Western Blot (WB) analysis of various lysates using NLRP12 Recombinant antibody (83123-6-RR)

    WB analysis using 83123-6-RR (same clone as 83123-6-PBS)

    Mouse liver tissue was subjected to SDS PAGE followed by western blot with 83123-6-RR (NLRP12 antibody) at dilution of 1:12000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83123-6-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83123-6-RR

    Affinity and Kinetic Characterization of 83123-6-RR

    Biolayer interferometry (BLl) kinetic assays of 83123-6-RR against Human NLRP12 were performed. The affinity constant is 0.236 nM.

Geprüfte Anwendungen

Produktinformation

83123-6-PBS bindet in WB, Indirect ELISA NLRP12 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen NLRP12 fusion protein Ag34281
Vollständiger Name NLR family, pyrin domain containing 12
Berechnetes Molekulargewicht 1061 aa, 120 kDa
Beobachtetes Molekulargewicht 95-110 kDa
GenBank-ZugangsnummerBC028069
Gene symbol NLRP12
Gene ID (NCBI) 91662
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

NACHT, LRR and PYD domains-containing protein 12 (NLRP12) is also named as Monarch-1, NALP12, PYPAF7 and RNO. NLRP12 is as an essential cytosolic sensor for heme plus PAMPs-mediated PANoptosis, inflammation, and pathology (PMID: 37267949). NLRP12 drives inflammasome and PANoptosome activation, cell death, and inflammation in response to heme plus PAMPs or TNF. TLR2/4-mediated signaling through IRF1 induced Nlrp12 expression, which led to inflammasome formation to induce maturation of IL-1β and IL-18 (PMID: 37267949). NLRP12, a pyrin-containing NLR protein, is a negative regulator of innate immune activation and type I interferon (IFN-I) production (PMID: 36719379).