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NLRP7 Rekombinanter Antikörper

NLRP7 Rekombinant Antikörper für IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241120A10

Kat-Nr. : 83996-4-PBS

Synonyme

NOD12, NALP7, NACHT, LRR and PYD domains-containing protein 7, HYDM, CLR19.4

Filter:
  • Immunofluorescence (IF) / fluorescent staining of K-562 cells using NLRP7 Recombinant antibody (83996-4-RR)

    IF Staining of K-562 using 83996-4-RR (same clone as 83996-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed K-562 cells using NLRP7 antibody (83996-4-RR, Clone: 241120A10 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 83996-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83996-4-RR

    Affinity and Kinetic Characterization of 83996-4-RR

    Biolayer interferometry (BLl) kinetic assays of 83996-4-RR against Human NLRP7 were performed. The affinity constant is 1.98 nM.

Geprüfte Anwendungen

Produktinformation

83996-4-PBS bindet in IF/ICC, Indirect ELISA NLRP7 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen NLRP7 fusion protein Ag27465
Vollständiger Name NLR family, pyrin domain containing 7
Berechnetes Molekulargewicht112 kDa, 115 kDa, 118 kDa
GenBank-ZugangsnummerBC109125
Gene symbol NLRP7
Gene ID (NCBI) 199713
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

NLRP7, also called NALP7 or PYPAF3, is a member of the NOD-like receptors (NLR), a family of proteins that plays a crucial role in the innate immune response. NLRP7 has been reported to emerge from NLRP2 gene. Similar to all inflammasomes, NLRP7 contributes to both pro- and an anti-inflammatory processes, depending on whether it functions in an inflammasome-dependent or independent pathway. The function of NLRP7 inflammasome has also been reported to depend on the master regulatory transcription factor protein that controls cellular inflammation, the NF-kB. In addition to its pro- and anti-inflammatory actions, NLRP7 plays a role in restricting intracellular bacterial replication and can also induce inflammasome assembly upon specific stimulation by FSL-1 (diacylated lipoprotein).