NLRP7 Rekombinanter Antikörper

NLRP7 Rekombinant Antikörper für IF/ICC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IF/ICC, ELISA

Konjugation

Unkonjugiert

CloneNo.

241120A10

Kat-Nr. : 83996-4-RR

Synonyme

NOD12, NALP7, NACHT, LRR and PYD domains-containing protein 7, HYDM, CLR19.4

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  IF Staining of K-562 using 83996-4-RR

  Immunofluorescent analysis of (4% PFA) fixed K-562 cells using NLRP7 antibody (83996-4-RR, Clone: 241120A10 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2).

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  Affinity and Kinetic Characterization of 83996-4-RR

  Biolayer interferometry (BLl) kinetic assays of 83996-4-RR against Human NLRP7 were performed. The affinity constant is 1.98 nM.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IF/ICC: K-562-Zellen

Empfohlene Verdünnung

• Immunfluoreszenz (IF)/ICC: IF/ICC : 1:125-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

83996-4-RR bindet in IF/ICC, ELISA NLRP7 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: NLRP7 fusion protein Ag27465
• Vollständiger Name: NLR family, pyrin domain containing 7
• Berechnetes Molekulargewicht: 112 kDa, 115 kDa, 118 kDa
• GenBank-Zugangsnummer: BC109125
• Gene symbol: NLRP7
• Gene ID (NCBI): 199713
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

NLRP7, also called NALP7 or PYPAF3, is a member of the NOD-like receptors (NLR), a family of proteins that plays a crucial role in the innate immune response. NLRP7 has been reported to emerge from NLRP2 gene. Similar to all inflammasomes, NLRP7 contributes to both pro- and an anti-inflammatory processes, depending on whether it functions in an inflammasome-dependent or independent pathway. The function of NLRP7 inflammasome has also been reported to depend on the master regulatory transcription factor protein that controls cellular inflammation, the NF-kB. In addition to its pro- and anti-inflammatory actions, NLRP7 plays a role in restricting intracellular bacterial replication and can also induce inflammasome assembly upon specific stimulation by FSL-1 (diacylated lipoprotein).