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NPHP5/IQCB1 Monoklonaler Antikörper

NPHP5/IQCB1 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

2A9F4

Kat-Nr. : 68404-1-PBS

Synonyme

IQ motif containing B1, IQCB1, KIAA0036, Nephrocystin 5, PIQ, SLSN5

Filter:
  • Western Blot (WB) analysis of various lysates using NPHP5/IQCB1 Monoclonal antibody (68404-1-Ig)

    WB analysis using 68404-1-Ig (same clone as 68404-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68404-1-Ig (NPHP5,IQCB1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68404-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

68404-1-PBS bindet in WB, Indirect ELISA NPHP5/IQCB1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG2a
Klonalität Monoklonal
Typ Antikörper
Immunogen NPHP5/IQCB1 fusion protein Ag8203
Vollständiger Name IQ motif containing B1
Berechnetes Molekulargewicht 598 aa, 69 kDa
Beobachtetes Molekulargewicht69 kDa
GenBank-ZugangsnummerBC005806
Gene symbol IQCB1
Gene ID (NCBI) 9657
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

IQCB1, also known as NPHP5, is a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. It has a central coiled-coil region and two calmodulin-binding IQ domains. Localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells, IQCB1 is thought to play a role in ciliary function. Mutations in this gene result in Senior-Loken syndrome type 5, a juvenile disorder characterized by defects in the waste filtering system of the kidney, as well as retinal degradation.