Nectin-2/CD112 Rekombinanter Antikörper

Nectin-2/CD112 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241798A11

Kat-Nr. : 98231-1-PBS

Synonyme

241798A11, CD112, Herpes virus entry mediator B, HveB, mHveB

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  FC experiment of NIH/3T3 using 98231-1-RR (same clone as 98231-1-PBS)

  1x10^6 NIH/3T3 cells were surface stained with 0.25 ug Anti-Mouse Nectin-2/CD112 Rabbit Recombinant Antibody (98231-1-RR, Clone: 241798A11)(red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98231-1-PBS in a different storage buffer formulation.

• 

  FC experiment of NIH/3T3 using 98231-1-RR (same clone as 98231-1-PBS)

  1x10^6 NIH/3T3 cells were surface stained with 0.25 ug Anti-Mouse Nectin-2/CD112 Rabbit Recombinant Antibody (98231-1-RR, Clone: 241798A11)(red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98231-1-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98231-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98231-1-RR against Mouse Nectin-2/CD112 were performed. The affinity constant is below 1 pM.

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Geprüfte Anwendungen

Produktinformation

98231-1-PBS bindet in FC Nectin-2/CD112 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Nectin-2/CD112 fusion protein Eg2019
• Vollständiger Name: poliovirus receptor-related 2
• Berechnetes Molekulargewicht: 57 kDa
• GenBank-Zugangsnummer: NM_008990.3
• Gene symbol: Nectin-2/CD112
• Gene ID (NCBI): 19294
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

Nectin 2, also named as PVRL2, CD112, HVEB, PRR2 and PVRR2, is an adhesion molecule widely expressed in cell lines of different lineages, including hematopoietic, neuronal, endothelial and epithelial cells. CD112 belongs to a new family of immunoglobulin-like molecules that includes four members (CD111, CD112, PRR3 and CD155) sharing an ectodomain made of three Ig domains, of V and C types. CD112 is expressed in the myelo-monocytic and megakaryocytic hematopoietic lineages and the function in hematopoiesis is currently unknown. CD112 is an intercellular homophilic adhesion. CD112 localizes specifically at adherents junctions via its cytoplasmic interaction with the scaffold F-actin binding protein afadin. Disruption of the murine CD112 gene leads to infertility of male mice with morphologically aberrant spermatozoa. CD112 mediates entry of some alphaherpesvirus mutants (also named HveB) via its V domain. CD112 is involved in cell to cell spreading of viruses.