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Nesprin1/Syne-1 Polyklonaler Antikörper

Nesprin1/Syne-1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 31095-1-PBS

Synonyme

SYNE1, MYNE1, Myne 1, Enaptin, CPG2

Filter:
  • Western Blot (WB) analysis of various lysates using Nesprin1/Syne-1 Polyclonal antibody (31095-1-AP)

    WB analysis using 31095-1-AP (same clone as 31095-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 31095-1-AP (SYNE1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31095-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

31095-1-PBS bindet in WB, Indirect ELISA Nesprin1/Syne-1 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Nesprin1/Syne-1 fusion protein Ag34809
Vollständiger Name spectrin repeat containing, nuclear envelope 1
Beobachtetes Molekulargewicht120 kDa, 367 kDa, 642 kDa, 1000 kDa
GenBank-ZugangsnummerBC039121
Gene symbol SYNE1
Gene ID (NCBI) 23345
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SYNE1, also known as spectrin repeat containing nuclear envelope protein 1. It is expressed in skeletal and smooth muscle, as well as peripheral blood lymphocytes, and localizes to the nuclear membrane. Mutations in the SYNE1 gene have been associated with several diseases, including autosomal recessive spinocerebellar ataxia type 8 (also referred to as autosomal recessive cerebellar ataxia type 1 or recessive ataxia of Beauce) and Emery-Dreifuss muscular dystrophy 4, autosomal dominant. The SYNE1 gene exhibits ubiquitous expression across various tissues, including the ovary and bone marrow. The molecular weight of the SYNE1 protein can vary depending on the specific isoform. For example, the full-length nesprin-1 isoform, also known as nesprin-1 giant, has 8797 amino acids and a molecular weight of approximately 1000 kDa. Another isoform, nesprin-1α2, has a molecular weight of about 120 kDa (PMID: 27782104). The protein has other isoforms with molecular weights of 380 kDa, 167 kDa and 642 kDa respectively.