NeutraControl IL-10 Monoklonaler Antikörper
NeutraControl IL-10 Monoklonal Antikörper für ELISA, Non-Neutralization
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
human und mehr (1)
Anwendung
WB, ELISA, Non-Neutralization
Konjugation
Unkonjugiert
CloneNo.
6C6E6
Kat-Nr. : 69518-1-Ig
Synonyme
Veröffentlichte Anwendungen
| WB | See 1 publications below |
Produktinformation
69518-1-Ig bindet in WB, ELISA, Non-Neutralization IL-10 und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| In Publikationen genannte Reaktivität | Maus |
| Wirt / Isotyp | Maus / IgG1 |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | human Humankine IL-10 protein HZ-1145 |
| Vollständiger Name | interleukin 10 |
| Gene symbol | IL-10 |
| Gene ID (NCBI) | 3586 |
| Konjugation | Unkonjugiert |
| Form | Lyophilized Powder |
| Reinigungsmethode | Protein-G-Reinigung |
| Lagerungspuffer | Sterile PBS |
| Endotoxin | <0.1 EU/μg |
| Wiederherstellung | This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use. |
| Stability and Storage | Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
Hintergrundinformationen
The human IL10 gene is 4.7 kb in size and is located on the long arm of chromosome 1. It contains five exons. Biologically functional IL-10 exists in the form of a 36 kDa homodimer composed of two non-covalently bonded mono-mers each with 160 amino acids length. IL-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
This antibody is a neutralizing control antibody for IL-10, the immunogen is the same as Neutrakine 69018-1-Ig but could not neutralize human IL-10.
Publikationen
| Species | Application | Title |
|---|---|---|
Cell Commun Signal Schistosome egg-derived extracellular vesicles deliver Sja-miR-71a inhibits host macrophage and neutrophil extracellular traps via targeting Sema4D | ||
Regen Ther Small extracellular vesicles derived from auricular chondrocytes promote secretion of interleukin 10 in bone marrow M1-like macrophages |

