NeutraControl IL-10 Monoklonaler Antikörper

NeutraControl IL-10 Monoklonal Antikörper für ELISA, Non-Neutralization

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human und mehr (1)

Anwendung

WB, ELISA, Non-Neutralization

Konjugation

Unkonjugiert

Publikationen(2)

CloneNo.

6C6E6

Kat-Nr. : 69518-1-Ig

Synonyme

CSIF, IL 10, IL10, IL-10, IL10A, interleukin 10, TGIF



Veröffentlichte Anwendungen

WBSee 1 publications below

Produktinformation

69518-1-Ig bindet in WB, ELISA, Non-Neutralization IL-10 und zeigt Reaktivität mit human

Getestete Reaktivität human
In Publikationen genannte ReaktivitätMaus
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen human Humankine IL-10 protein HZ-1145
Vollständiger Name interleukin 10
Gene symbol IL-10
Gene ID (NCBI) 3586
Konjugation Unkonjugiert
Form Lyophilized Powder
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer Sterile PBS
Endotoxin<0.1 EU/μg
WiederherstellungThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Hintergrundinformationen

The human IL10 gene is 4.7 kb in size and is located on the long arm of chromosome 1. It contains five exons. Biologically functional IL-10 exists in the form of a 36 kDa homodimer composed of two non-covalently bonded mono-mers each with 160 amino acids length. IL-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

This antibody is a neutralizing control antibody for IL-10, the immunogen is the same as Neutrakine 69018-1-Ig but could not neutralize human IL-10.

Publikationen

SpeciesApplicationTitle
mouseWB

Cell Commun Signal

Schistosome egg-derived extracellular vesicles deliver Sja-miR-71a inhibits host macrophage and neutrophil extracellular traps via targeting Sema4D

Authors - Yao Liao

Regen Ther

Small extracellular vesicles derived from auricular chondrocytes promote secretion of interleukin 10 in bone marrow M1-like macrophages

Authors - Tetsuya Kobatake