NeutraKine® IL-10 Monoklonaler Antikörper

NeutraKine® IL-10 Monoklonal Antikörper für IHC, Neutralization, ELISA, Sandwich ELISA, Indirect ELISA, Sample test

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

IHC, Neutralization, ELISA, Sandwich ELISA, Indirect ELISA, Sample test

Konjugation

Unkonjugiert

CloneNo.

1E4F5

Kat-Nr. : 69018-1-PBS

Synonyme

IL-10, IL-10,IL10, 1E4F5, CSIF, IL 10



Produktinformation

69018-1-PBS bindet in IHC, Neutralization, ELISA, Sandwich ELISA, Indirect ELISA, Sample test NeutraKine® IL-10 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen human Humankine IL-10 protein HZ-1145
Vollständiger Name interleukin 10
Gene symbol IL-10
Gene ID (NCBI) 3586
Konjugation Unkonjugiert
Form Lyophilized Powder
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
Endotoxin<0.1 EU/μg
WiederherstellungThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Hintergrundinformationen

Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

This antibody can be used to neutralize the bioactivity of IL-10.