NeutraKine® IL-10 Monoklonaler Antikörper
NeutraKine® IL-10 Monoklonal Antikörper für ELISA
Wirt / Isotyp
Maus / IgG2b
Getestete Reaktivität
human
Anwendung
, ELISA
Konjugation
Unkonjugiert
CloneNo.
7B8G3
Kat-Nr. : 69018-2-Ig
Synonyme
Galerie der Validierungsdaten
Produktinformation
69018-2-Ig bindet in , ELISA NeutraKine® IL-10 und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| Wirt / Isotyp | Maus / IgG2b |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | human Humankine IL-10 protein HZ-1145 |
| Vollständiger Name | interleukin 10 |
| Gene symbol | IL10 |
| Gene ID (NCBI) | 3586 |
| Konjugation | Unkonjugiert |
| Form | Lyophilized Powder |
| Reinigungsmethode | Protein-A-Reinigung |
| Lagerungspuffer | Sterile PBS. |
| Endotoxin | <0.1 EU/μg |
| Wiederherstellung | This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use. |
| Stability and Storage | Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
Hintergrundinformationen
Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, and autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
This antibody can be used to neutralize the bioactivity of IL-10.
